Index
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Pharmacology and drugs - introduction

Drug, pharmacology and therapeutic Methods for studying drugs
Criteria of validity of a method of measurement, Drug trials, Analyzes and interpretation of the results of a trial
Steps in drug discovery and development
Study of the physicochemical characteristics, Study in animals or pre-clinical testing, Clinical pharmacology or evaluation of drugs in humans
General characteristics of the effects of drugs
Effects of one drug, Drug interactions, Adverse effects drugs and Pharmacovigilance
Mechanism of action drugs on the molecular level
General characteristics of molecules, Requirements for a molecular interaction, Consequences of the interaction
Pharmacokinetics
Definition of the main pharmacokinetic parameters, Evolution of plasma concentrations of a drug after a single administration, Evolution of plasma concentrations of a drug after repeated administrations, Passage of drugs across membranes, Routes of drug administration, Drug distribution from blood, Tissue distribution of drugs , Biotransformations, Elimination of drugs, Pharmacokinetics and dosage of drugs

Pharmacokinetics - illustrations
Single administration by intravenous route, 3 different doses of the same drug. Decrease of plasma concentration versus time. One compartment model, Single administration by intravenous route, 3 different doses of the same drug. Decrease of plasma concentration plotted on a semi-logarithmic scale, Single administration by intravenous route of drugs with different T1/2, Intravenous administration of 3 drugs with different T1/2 - Decrease of plasma concentration plotted on a semi-logarithmic scale, Intravenous administration of a drug by continuous infusion at constant rate, Single administration of the same drug by intravenous and oral routes, Single administration by oral route of the same drug at different doses, Single administration by oral route of 3 drugs with different intestinal absorption rates, Repeated administrations by oral route, Repeated administrations, influence of the dose, Repeated administrations by oral route, influence of T1/2, Repeated administrations by oral route, influence of frequency of administrations

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