Single administration by intravenous route, 3 different doses of the same drug. Decrease of plasma concentration plotted on a semi-logarithmic scale

On a semi-logarithmic scale, an exponential decrease gives a straight line. T1/2 of a drug is generally independent on the dose and here the straight lines are parallel. The time necessary to obtain a concentration decrease from 100 to 50 units is the same than to obtain a decrease from 10 to 5.

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