Cyclooxygenase inhibitors, NSAID - Pyrazole derivatives
Phenylbutazone, a pyrazol derivative, is one of the oldest NSAID and also one of the most active but it is used relatively little because of the agranulocytosis which it can elicit.
There are other derivatives of pyrazole such as phenazone also called antipyrin and noraminopyrine also called noramidopyrine, noraminophenazone, metamizole and dipyrone. These two compounds are present in many proprietary formulations either alone or combined with other active principles. They are effective analgesics whose mechanism of action is not well known. The name metamizole should not lead us to forget that it is a derivative of the aminopyrine which was withdrawn from the market because it caused agranulocytosis.
The efficacy of phenylbutazone as an anti-inflammatory drug and noramidopyrine as an antalgic is certain, but the risk of agranulocytosis restricts their use.
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