Cyclooxygenase inhibitors, NSAID - Leukotrienes receptors antagonists

The eicosanoids of which one wishes to inhibit the effects are thromboxanes and leukotrienes.

Among thromboxane receptor antagonists, seratrodast is a thromboxane A 2 antagonist under development for preventive treatment of asthma.

The cysteinyl-leukotrienes, LTC4, LTD4 and LTE4 cause bronchoconstriction, increase vascular permeability and activate eosinophil migration. The antagonists of leukotriene receptors, whose international common name ends in – lukast, are pranlukast, zafirlukast and montelukast; they inhibit the effects of leukotrienes.

Montelukast is used as an adjunct to corticoids or to beta-2-adrenergic agonists in the preventive treatment of asthma and not in the curative treatment of attacks. It is administered by oral route, a tablet to take preferably the evening at bedtime. Montelukast is extensively metabolized by cytochromes CYP 3A4 and CYP 2C9.  



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Quizz : Q 102
Montelukast is:
an antagonist of leukotrienes receptors
used in the preventive treatment of asthma
an antibiotic active against the Koch bacillus
a beta- 2- mimetic
an adenosine receptor antagonist  

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107 The drugs whose generic name (internation...

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