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Cilostazol in prevention of strokes

Author : Pierre Allain Date : 2010-10-25

We already spoke about cilostazol, Pletal*, in Pharmacorama. It was marketed in France as Pletal* with the indication intermittent claudication.

A paper published online September 11, 2010 in the Lancet mg compares the efficacy of cilostazol at the dose of 100 mg twice daily to that of aspirin 81 mg daily for the prevention of strokes, in  patients having had an ischemic stroke of non-cardioembolic origin.

The incidence of stroke was approximately the same in the cilostazol group and in the aspirin group, cilostazol was not inferior to aspirin for preventing strokes, and caused less of hemorrhagic stroke than aspirin but more more adverse effects: headache, palpitations, tachycardia, diarrhea and dizziness. 

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