Treatment of overactive bladder syndrome
| Author : Pierre Allain |
Date : 2012-5-2 |
Overactive bladder syndrome is characterized by urinary disorders, in particular an imperative need to urinate the bladder not being full, with often incontinence, in the absence of urinary tract infection.
A review published on April 17th, 2012 in the BMJ concerns management of overactive bladder syndrome. It considers various non drug interventions but we only will retain what is related to drugs. Diuretics by increasing diuresis can worsen the symptoms; adrenergic alpha-1 antagonists (alpha-1 blockers), can worsen incontinence by relaxing the vesical neck. Caffeine and alcohol which increase diuresis can increase the symptoms.
The drugs generally used for the treatment of hypereractive bladder are anticholinergics: oxybutinin, trospium, solifenacin, tolterodine. The most frequent adverse effects of anticholinergic drugs are dryness of the mouth and constipation.
The recourse to botulinic toxin can be considered in particular cases.
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