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Glycopyrronium or glycopyrrolate, a muscarinic receptor antagonist

Author : Pierre Allain Date : 2010-10-24

Glycopyrronium, also called glycopyrrolate, has been known for about fifty years. It is an anticholinergic agent, more precisely a muscarinic receptor inhibitor. Chemically, glycopyrronium contains a quaternary ammonium, which explains its poor absorption from the digestive tract and its low passage through the blood-brain barrier. It is mainly used in anesthesia and given parenterally. It is marketed in different countries especially as Robinul*.

Glycopyrrolate has been marketed in the U.S. in July 2010 as Cuvposa*, oral solution, with the indication excessive salivation in children with neurological disorders, see note of the FDA.

Glycopyrrolate has atropine-like adverse effects, to know more, see Atropine.

We indicate the chemical formula of glycopyrronium below:


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