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Liposomal amphotericin B in the treatment of the visceral leishmaniasis

Author : Pierre Allain Date : 2010-2-15

Visceral leishmaniasis, kala-azar, is a parasitic disease caused by Leishmania donovani, prevailing in particular in certain areas of India.

Amphericin B is one of the main treatments of leishmaniasis but it necessitates a series of intravenous infusions when deoxycholate amphericin B is used.

A paper published in the NEJM of February 11th, 2010 compares the efficacy and the safety of deoxycholate amphotericin B in intravenous infusion at 1 mg per kilogram every other day during a month (15 infusions) with those of liposomal amphotericin B, at 10 mg per kilogram in a single infusion. The two types of administration of amphotericin B gave the same results concerning efficacy and safety.

For the treatment of visceral leishmaniasis liposomal amphericin B seems a better choice than the deoxycholate form.

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