Mechanism of action drugs on the molecular level

Drugs are molecules, sometimes elements, which interact in a generally specific way with some of the endogenous molecules that they meet. These interactions induce their beneficial and adverse effects as well as their own biotransformations. They can also interact with the components of a microorganism, bacterium, virus, parasite…

The majority of drugs have a low molecular weight, lower than 1000. When their molecular weight is high, they are generally polypeptides having similarities with endogenous molecules.

The endogenous molecules on which drugs act are almost always macromolecules: enzymes, receptors, channels, which are called targets.

The bonds which are established between drugs and their targets are sometimes covalent but generally interactions of low energy.

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