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Ingenol mebutate for actinic keratosis

Author : Pierre Allain Date : 2012-4-21

Ingenol mebutate, also called PEP005, is a substance found in the sap of Euphorbia peplus. Recent papers showed the interest of the ingenol mebutate gel, used as topical application, for treating actinic keratoses.

A paper published in the NEJM, March 15, 2012 shows that ingenol mebutate gel applied on actinic keratosis once daily during two or three days, induces, after an irritating phase during the first week, a considerable reduction of the importance of lesions within one or two months.

The indication of ingenol mebutate is rather similar to that of topical fluorouracil, Efudix*, which, requires 1 to 2 daily applications for 3 to 4 weeks.

 In the US ingenol mebutate can be found as Picato*.

Chemical formula of ingenol mebutate:


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