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Bacterial transcription inhibitors

RNA polymerase ensures the transcription of the information contained in DNA from DNA to mRNA. The gene, fragment of DNA, is the informational unit. Transcription of DNA into mRNA is done in the presence of ATP, UTP, GTP and CTP through RNA-polymerase-DNA-dependent, which catalyzes the elongation of the chain. The activity of RNA polymerase is controlled by activator and repressor proteins.

The reading for transcription begins at the promoter, area of regulation of the coding domain of DNA. The RNA-polymerase identifies the promoter, binds to it. Initiation elicits the spacing of the two strands which constitute a bubble where transcription is carried out. mRNA, resulting from the transcript, undergoes modifications or maturation such as intron splicing, to be converted into a functional structure .

Rifamycins, macrocyclic antibiotics produced by Streptomyces mediterranei, inhibit the bacterial RNA polymerase, by binding to the beta subunit, which is one of the five subunits of the enzyme: They have little action on the human RNA polymerase. This group of antibiotics includes rifampicin, rifabutin and rifamycine SV.

  • Rifapentine

    Rifapentine is a rifampin analog used in certain countries for tuberculosis therapy.

 

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  Last update : July 2009  
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