Alpha-2 adrenergic receptors antagonists
Inhibition of presynaptic adrenergic alpha-2 receptors elicits an increase in noradrenaline release with peripheral consequences (tachycardia, rise of arterial pressure) and central consequences (excitation, tremors, hyperactivity, antidepressant effect). Inhibitors of these receptors are yohimbine, mianserin and mirtazapine.
Yohimbine is a nonspecific inhibitor of the presynaptic alpha-2 adrenergic receptors. It has little therapeutic uses; it has been proposed in the treatment of erectile dysfunction and postural hypotension.
| Yohimbine |
APHRODYNE* Caplets |
Mianserin and mirtazapine are antagonist of central alpha-2 presynaptic adrenergic receptors which have an antidepressant effect. Idazoxan is another antagonist of alpha-2 receptors.
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