Indirectly acting cholinomimetic agents - Increase of synthesis
The diet of an adult supplies approximately 0,5 to 1 g of choline per day in free and esterified form. Attempts to increase acetylcholine synthesis by choline administration, in Alzheimer disease for example, did not give convincing results. Choline acts as a methyl donor and its absence in diet induces hepatic steatosis. Choline is present in many multi-ingredient proprietary medical preparations.
Other compounds, involved directly or indirectly in acetylcholine synthesis are: betaine, phosphorylcholine, phosphatidylcholine and cytidine diphosphocholine, called citicoline or CDP-choline. The latter has been proposed in the treatment of strokes and cranial traumatisms.
|
