Cyclooxygenase inhibitors, NSAID - Leukotrienes receptors antagonists
The eicosanoids of which one wishes to inhibit the effects are thromboxanes and leukotrienes.
Among thromboxane receptor antagonists, seratrodast is a thromboxane A 2 antagonist under development for preventive treatment of asthma.
The cysteinyl-leukotrienes, LTC4, LTD4 and LTE4 cause bronchoconstriction, increase vascular permeability and activate eosinophil migration. The antagonists of leukotriene receptors, whose international common name ends in – lukast, are pranlukast, zafirlukast and montelukast; they inhibit the effects of leukotrienes.
 
Montelukast is used as an adjunct to corticoids or to beta-2-adrenergic agonists in the preventive treatment of asthma and not in the curative treatment of attacks. It is administered by oral route, a tablet to take preferably the evening at bedtime. Montelukast is extensively metabolized by cytochromes CYP 3A4 and CYP 2C9.
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