Pentoxiphylline, also called oxpentifylline, another xanthine derivative
Pentoxifylline also called oxpentifylline is a xanthine derivative whose pharmacological properties differ from those of caffeine and theophylline. The mechanisms of action responsible for its characteristics are not well-known.
Pentoxifylline increases the deformability of red blood cells, which facilitates their circulation in capillaries of low diameter, and improves tissue irrigation. It lowers the concentration of blood fibrinogen. It reduces, moreover, the production and the effects of interleukin 1 and Tumor necrosis factor. Pentoxifylline is indicated for the treatment of patients with intermittent claudication related to chronic occlusive arterial disease of the limbs. It has been proposed for the treatment of certain septic shocks where there is hypersecretion of TNF.
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